SIDEROBLASTIC ANEMIA

DIETARY IRON

Spleen

Bone Marrow

Sternum, Pelvis, Vertebrae

Pluripoint stem cells

Decreased heme production

Increased Iron

Iron accumulates in mitochondria

Build up of ribosomes

Mitochondria surround nucleus

Excess Iron Deposits

Immature RBCs

Excess Iron builds up in organs and cause damage

Basophilic stimpling

Liver

Iron stored as Ferritin

Lungs

Decreased RBC increase serum iron

Arterial System

Body Cells

Heart

Brenda Mitchell

Stomach

Small Intestine

ETOH abuse

Mitochondrial damage

Vitamin B 6 deficiency

Mitochondria's ability to form Heme

Lead Poisoning

Denatures enzymes necessary for Heme synthesis

Denatures ribonuclease - build up of ribosomes in RBC

Ringed Sideroblast

Diagnostic Lab

CBC

MCV

Normal or High

Peripheral blood smear

Basophilic stipling

Pappeheimer bodies in RBC

Iron studies

Increased serum iron

Increased ferritin

Decreased Total Iron Binding capacity