TREATMENT OF DM: ORAL HYPOglycaemics

Examples:

INCREASE insulin secretion

High initial response

No lag period b4 response

Effective, well-tolerated & widely used

Shud not give glibenclamide & chlorpropamide (=long-acting) 2 over 70s if live alone - fatal

S.Es

WEIGHT GAIN by increasing inulin secretion

Hypoglycaemia

Secondary failure rate = 5-10% per yr