によって Michael Endress 11年前.
458
SolveSCI
によって Michael Endress 11年前.
458
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A-Cell Product
•Resorbable acellular porcine xenograft
• Intrathecal NT-3, delivered at the time of injury, promoted an upregulation of the growth-associated protein GAP-43
• Regeneration of cholera toxin B-labeled sensory axons across the DREZ and deep into the dorsal horn.
• Appearance of ED-1 expressing phagocytes marked end of effective treatment period of NT-3
• If treated within treatment period, regeneration continued, but in grey matter, not white.
In vivo studies have revealed remarkable long-distance regeneration of adult axons though CNS white matter tracts after enzymatic treatment to digest these proteoglycan side chains (Steinmetz, et al., 2005)
Injured corticospinal fibers and uninjured serotonergic fibers increase sprouting after enzymatic treatment to remove sugar epitopes (Barritt et al., 2006)
Enzyme which degrades Chondroitin Sulfate Proteoglycan shows local efficacy in enhancing axonal growth. (Cafferty et al., 2007)
• Chondroitinaise ABC (ChABC) was enzyme used to degrade chondroitin sulfate proteoglycan
•Axonal regrowth in lesion but not below it
• No significant motor function recovery
• Sensory recovery
Removing or preventing the production of sugar epitopes on proteoglycan molecules allows for axonal regeneration. (Bradbury, et al., 2002; Grimpe and Silver, 2004; McKeon, et al., 1995; McKeon, et al., 1991; Steinmetz, et al., 2005)
