Categories: All - drugs - contraction - cardiovascular - hypertension

by Mindy Anderson 1 year ago

109

Cardiovascular Drugs

Medications used to manage cardiovascular conditions encompass a variety of drug classes, each targeting specific aspects of heart function and blood pressure regulation. Cardiac glycosides like digoxin enhance heart contraction but require careful monitoring for toxicity.

Cardiovascular Drugs

Cardiovascular Drugs

Pump (heart contraction)

Antiarrhythmics
Class IV

Tx for HTN, angina

Phase 2: block calcium channels, delay phase 1&2

diltiazem, verapamil (CCB)

Class III

Tx for V-fib, pulseless v-tach, cardiac arrest

Phase 3: block K+ channels

amiodarone, sotolol

Class II

Tx for SVT, PVC

Phase 4: prolongs rest phase decrease BP, workload

Beta blockers -lol

Class I

Tx for V-tach

Phase 0: block Na+ channels

Lidocaine, flecainide

CHF
Cardiac Glycosides

dig toxicity

check heart rate

make heart beat slower & harder

Digoxin

PDE inhibitors

Don't give with Lasix

AE: ventricle arrhythmias

increase contraction & increase SNS stim.

Milrinone. IV only

HCN blockers

caution w/ A-fib & heart block

AE: bradycardia, HTN, a-fib

slows SA node improves cardiac output

Ivabradine

AntiHTN
SNS blockers

check HR before administering

lower BP, lower HR

Block SNS response

Beta-blockers -lol

Diuretics

Pt. ed. reasons for med & compliance

1st line med for HTN

increase Na+ & water excretion frim kidneys

hydrochlorothiazide, spironolactone

vasodilators

monitor pt. w/ CAD, CHF, tachycardia

lower BP, causes tachycardia

used in severe HTN emergencies

hydralazine, minoxidil, nitroprusside

AE: low BP S&S

slows contractility & impulses dilates arteries

inhibit movement of Ca+ in action potential Phase 2

-dipine

ARBs

AE: low BP S&S renal damage

lowers BP

block angiotensin II receptors

-sartan

ACE inhibitors

take on empty stomach

treats HTN

decrease BP decrease aldosterone

block angiotensin-converting enzyme=no Angiotensin II

-pril

AntihypoTN
Long term: midodrine (PO)
Short term: Norepi, epi, phenylephrine (all IV)
Stimulate SNS response
Increase BP, blood volume, & heart contraction

Plasma (blood)

Anemia Tx.
Epo stimulation

Monitor: HTN, seizures, Hgb level

IV or subq only

CKD, dialysis, cancer

epoetin alfa

Other anemias

Monitor GI & bone marrow

sickle cell: hydroxyurea, ABX

Megaloblastic: Folic acid, Vit. B12

iron deficiency

Diarrhea, dark stools

Z-track or PO

elevate serum iron

ferrous-

Anticoagulants
Antidotes: warfarin=Vit. K heparin=protamine sulfate Eliquis & Xarelto=Andexxa
PE, DVT, A-fib
Interferes w/ clotting cascade
Antiplatelets
Aspirin, Plavix, Brillinta
Good pt. teaching
Know pt. hx.
CVD, CAD, PAD
Slippery platelets

Antianginals

CCB
coronary artery spasms HTN, angina
decrease workload decrease HR decrease O2 needs
vasodilation
diltiazem, verapamil, -pine
Beta blockers
Subtopic
decrease HR decrease contractility decrease BP
Tx. for HTN, angina
-lol, metoprolol
Nitros
Monitor HR & BP
Dizziness, headache, SOB
decrease preload decrease workload
Dilates blood vessels
Nitroglycerin, Nitro paste

Pipes (blood vessels)

cholesterol absorp. inhibitors
bloating, cramping
Take alone. 2-4 hrs.
lower cholesterol absorption
Ezetimibe
bile acid sequesterase
Limits fat sol. Vitamin absorption
Pt. compliance issues
4-6x/day
Binds with bile
Cholestyramine
HMG-CoA
Rhabdo & cataracts
Monitor liver
Blocks cholesterol synthesis
Statins