pull on edges
exerts force on
lays down
organization of
increase in tensile strength
restores
secondary
primary
lays down
follow macrophages to repair
behind margin
at margin
provides
proliferation of cells leads to
leads to
synthesized
synthesized
synthesized
stimulates
promotes
causes
induces
interferes with
regulates
promotes
stimulates
attracts
increases
increases
secrete
destroys & removes
followed by
enter
initiates
allows
allows
secrete
including
release
from site
from blood
release
causes release of
leads to
influences release of
increases
from mast cells
Ca2+
forms
triggers
Activated XIII
XIII
Ca2+
Ca2+
Ca2+ & V
Ca2+
releases
release of
adapts & begins
fails to adapt leading to
promotes
promotes
continue to destroy & remove
increases
attract
signals
Ca2+ & V
increase
increases
convert to
promotes

cell injury

cell death

healing process

1. hemostasis

vessel spasm/smooth muscle reaction

platelets come into contact with collagen

activation and aggregation of platelets

blood coagulation

extrinsic

tissue factor

Activated X

prothrombinase = common

prothrombin

thrombin

fibrinogen

loose fibrin threads

strengthened fibrin threads

clot formed

Activated XIII

intrinsic

Activated platelets

platelet phospholipids

Activated XII

Activated X

cytokines

histamine

vasodilation
&
capillary permeability

chemotactic factors

leukocyte infiltration

cytokines & GFs

keratinocytes

stored IL-1s

2. inflammation

platelets

blood-clotting proteins

immune cells

mast, dendritic, and other APCs

vessel dilation &
constriction factors

exudate to area &
increase edema

leukoctyes to site

neutrophils

bacteria & debris

macrophages

cytokines

histamine

vasodilation

capillary permeability

chemotactic
factors

leukocytes to
area of
phagocytosis

platelet activating
factors

platelet
aggregation

leukocyte adhesion
to endothelium

interleukins

immune response

interferons

unwanted
DNA/RNA
replication

tumor necrosis
factor alpha

proinflammatory
effect

arichidonic acid
derivatives

leukotrines

smooth
muscle
contraction

prostaglandins

neutrophil chemotaxis

pain receptors

cascade by degranulating

3. proliferation

epithelial cells

vascularization

new blood supply

repithelialization

horizontal
mitotic
growth

vertical
differentiation

fibroblasts

damage to CT

granulation tissue components

collagen type III

glycosaminoglycans

fibronectin

elastin

tissue fibroblasts

GFs

4. maturation

regeneration

original structure
& function

repair

reconstruction

collagen

type III to I

crosslinking

maturation

myofibroblasts at damaged area

new CT

fibrous elements

smaller opening/skin stretched