PET Radiopharmaceuticals
Ga-68 Dotatate
Localization of somatostatinreceptor positive neuroendocrine tumors (NeTs)
Somatostatin receptor.
68 Min.
N-13 Ammonia
Myocardium rest and stress imaging and evaluate for CAD.
Analog of ammonia. Distributed to all organs. Diffusion across capillary membrane, then metabolic conversion.
9.96 Min.
Rb-82 Chloride
Myocardium rest and stress imaging and to evaluate for CAD.
Analogous to Potassium (K+). Ion exchange.
Half-Life:
76 Sec.
F-18 Fluciclovine(Axumin)
Imaging in men for prostate cancer (based on PSA levels).
Amino acid transport across mammalian cell membranes.Taken up by prostate cancer cells.Active transport.
F-18 Sodium Fluoride
Skeletal imaging- Define areas of altered osteogenic activity.
Accumulates in skeleton in an even fashion. Ion exchange.
Half Life:
F-18 Florbetapir(Amyvid)
Alzheimer’s & cognitive decline disorders. Estimate B-amyloid neurotic plaque.
Binds to B-amyloid plaques in the brain. Passive diffusion.
F-18 Florbetaben(Neuraceq)
Estimating B-amyloid plaque density in patients with cognitive decline. (Alzheimer’s).
Binds to B-amyloid plaques in the brain. Crosses the BBB. Passive diffusion.
F-18 FDG
Uses:
Abnormal glucose metabolism
Cardiac viability- CAD and L. ventricular dysfucntion.
Brain imaging- associated with foci of epileptic seizures.
Oncology- Assessment of with suspected cancer.
MOL:
Glucose analog. Metabolism. Passive diffusion
Half life:
110 Min.
