Categorii: Tot - receptor - drugs

realizată de Darren Nguyen 15 ore în urmă

5

Receptor Theory

Paul Ehrlich's receptor theory highlights the necessity of drug binding for therapeutic effects, dismissing any notion of supernatural influence from the mere presence of drugs. The theory emphasizes direct interaction with tissue and explores the quantitative aspects of drug combinations, such as synergistic, potentiating, and additive effects.

Receptor Theory

Receptor Theory

Safety

Certain safety factor
Therapeutic Index

Desensitization

physiological adaptation
altered drug metabolism
exhaustion of mediators
translocation of receptors
altered conformation of receptors
tolerance

Combinations

synergistic/potentiating
additive

Antagonism

chemical
physiological
signaling blockade
pharmacokinetic
allosteric

Potency

effective concentration
effective dose

Quantitative aspects

Drug Receptor interaction

equilibrium dissociation constant
logarithmic
linear

Drug-receptor binding

Activation
governed by efficacy
Occupation
governed by affinity

Drug targets

enzymes
carriers/transport molecules
Ion channels
Membrane receptors

Specificity defined by:

site specificity
ligand specificity
High structural conservation

Paul Ehrlich proposed:

Drugs don’t have any supernatural properties by which their mere presence causes an effect
A drug will not work unless it is bound
Drugs require direct interaction with tissue