Block 4 Young Review

Больше похоже на это

Error Analysis

от ADA LUCIA ASENCIO RIVERA

Teacher mind map with quotes

от Mindomo Team

Mentefacto "Feedback"

от ANGIE ACHICANOY

Gout

от Reem Elsaman

Nucleotide Metabolism Synthesis of Purines & Pyrimidines

Pyrimidine Production

Degradation

ALL ARE water soluble ==> NO KIDNEY STONES

Thymine --> CO2, NH4+ and beta-aminoisobutyrate

Uracil --> CO2, NH4+ and beta-alanine

Cytosine ---> de-aminated ===> Uracil

Production

Salvaging

Nucleotides ------phosphorylase-----> nucleosides

Glutamine + CO2 + 2ATP ----> Carbamoyl Phosphate

Enzyme: (CPS-II) Carbomoyl Phosphate Synthase II

POS Feedback: PRPP

NEG FeedbacK: UTP

Purine production

Ribonucleotide Reductase (RR)

Regulation:

Nucleotides -------> deoxynucleotides

Nucleosides ----> uric acid

Excess uric acid ----> GOUT!

Via slavaging dietary nucleotides Nucleotides ---> nucleosides

Inosine ---->Hypoxanthine -----> Xanthine -----Xanthine oxidase--------> Uric Acid

Allopurinol inhibits xanthine oxidase! => less uric acid --> less gout!

Adenosine -------adenosine deaminase-------> Inosine

When broken down = SIDS "bubble boy"

Hypoxanthine ------HGPRT-----> IMP

When broken down = Lesch–Nyhan Disease

Adenine ---APRT----> AMP

when broken down = Kidney Stones

Negative Feedback

GDP and ADP inhibit -->

PRPP synthase

AMP inhibits-->

Adenylosuccinate synthase

GMP inhibit -->

GMP, GDP, & GTP inhibit--->AMP, ADP, & ATPinhibit--->

Glutamine phosphoribosyl amindotransferase

Purine Nucleotide Cycle in muscle cells

Releases NH3

IMP + Aspartate ===> AMP + Fumarate

IMP + ATP + Glutamine ==> GMP

IMP + GTP + Aspartate ==> AMP

PRPP + GLUTAMINE -------> IMP

IMP dehydrogenase

inhibited by mycophenolic acid

IMP is "branch point" b/t ATP and GTP synthesis

Enzyme Glutamine Phophoribosyl Amino Transferase

Ribose 5-P + ATP -----> PRPP

Enzyme PRPP Synthetase