Lipid metabolism
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Fate of absorbed
lipids
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Oxidation for production
of energy
Glucose formation by
gluconeogenesis:
Regulation of
lipogenesis
During fasting is inhibited by
anti-insulin hormones as glucagon are
secreted and increase lipolysis.
After meal : stimulated by
insulin
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Fate of glycerol and
fatty acids
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Fate of glycerol
1) Glucose by Gluconeogenesis.
2) Pyruvate by glycolysis.
3) Triacylglycerol by lipogenesis
Fate of fatty acids:
1) Oxidation by tissues to give energy.
2) May remain in adipose tissue to be re
esterified into triacylglycerol again
Dietary digestion
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2. In small intestine
a) pancreatic lipase
1. In stomach
a) lingual lipase
b) Gastric lipase
Lipid Malabsorbtion
Orlistat, an antiobesity drug
Caused by a defect in lipid
digestion or absorption.
IMPORTANCE OF
LIPIDS IN DIET
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Lipids supply the body with fat soluble
vitamins.
Lipids make diet palatable
Lipids are one of the main sources of
energy in the body
product of
lipid digestion
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4. Phospholipids
3. glycerol
2. Fatty acids
1. Monoacylglycerols
control of lipid digestion
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Secretin:
➢ Causes the pancreas to release a
solution
rich in bicarbonate that helps
neutralize
he pH of the intestinal contents
CCK:
➢ Acts on the gallbladder and pancreas
