SSRIs

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Selective Serotonin Reuptake Inhibitors (SSRIs)

Prototype Drug

Prozac (trade)

fluoxetine (generic)

Med examples

vortioxetine (Brintellix)

vilazodone (Viibryd)

paroxetine (Paxil)

sertraline (Zoloft)

fluoxetine (Prozac)

escitalopram (Lexapro)

citalopram (Celexa)

Nursing Considerations

* use cautiously in adolescents and or depressed/suicidal pts, as suicidal thoughts/actions could increase * avoid use in pts w/impaired renal or hepatic function or diabetes * renal/liver function tests before beginning therapy * do not use an SSRI in combination with a MAOI * do not use an SSRI in combination with St John's wort

Off label uses

generalized anxiety disorder

reducing diabetic neuropathy pain

treatment of migraine

Side Effects/Adverse Effects

insomnia, sweating, pruritis, cough, dyspnea, suicidal ideation, changes in taste, tremor, agitation

Mechanism of Action

Conditions Treated: * depression * bulimia * OCDs * panic disorders

Therapeutic Effects: * ease symptoms of depression * make extra serotonin available to the brain cells

blocks the reuptake of serotonin and increases its concentration in the synaptic cleft.