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Reptiles and amphibians have major physical differences. Reptiles have dry and scaly skin, whereas amphibians feel moist and sometimes rather sticky. They are vertebrates and cold blooded like amphibians. As compared to reptiles, amphibians have smooth skin. The skin of most amphibians is not water-proof unlike reptiles. Although most of the amphibians have lungs, they usually breathe through their skin and lining of their mouth, whereas most reptiles do not. Most amphibians have four limbs. Limbs and lungs are for adaptations of life on land and distinguish them from reptiles.