作者：Lindsay Treppa 5 年以前
233
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heterodimerization with retinoid X receptor
often causes dissociation of co-repressor
co-activating protein
Heat shock proteins in cytoplasm
Dissociation from HSP
HRE on target genes
Recruit co-activators/repressors that effect gene transcription
Hybrid
Endocrine
RXR heterodimers
Lipid ligands
Intranuclear heterodimers
Endocrine ligands
Cytoplasmic homodimers
Psychoactive drug targets
Binding of GABA to alpha/beta interface
Central aqueous pore
Activation of channel
2 ACh binding regions
Sequence homology
Ligand binding
Ion pore
Ion passage
Associate with cytosolic tyrosine kinases
GFR
Response to bacterial infection
GFs
Allows binding of independent cytoplasmic kinase
Activation of other proteins, transcription factors
proteins bound to activated intracellular domains
Recognizes phopshotyrosine domain
2. Release subunits
Beta and gamma reunite with dissociated alpha, await recycle
Alpha subunit switches off by self-hydrolysis of GTP
1. GDP --> GTP
Alpha, beta, gamma subunits
associate with ligand-bound receptors
20 alpha isoforms
some activate, some inhibit
Calcium sensor
GABA
ligand binding domain
peptide hormones
extracellular helices or hoops bind ligands
Amine NT, NP, purines, cannabinoids
