ASTHMA 2

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Topic flotante

Bibliografy: Borja G. Cosio, Rodriguez J, Rosado, y Fiorentino F. Asthma: Epidemiology, Pathophysiology, and Risk Factors Clinical Respiratory Medicine, Chapter 38, 487-500. Río B. Navarro E. Castro M. Sierra J. Asthma. Departamento de Alergia, Hospital Infantil de México Federico Gómez, México, D. F., México. Vol 66.

Physiopathology

Hyperreactivity of the respiratory tract

Narrowing of the airways in response to a known or unknown stimulus

Variable airflow limitation and intermittent symptoms

to both inflammation and repair of the airways

increased volume or contractility of smooth muscle cells

excessive airway contraction due to inflammatory changes

Response to sensory stimuli in sensory nerves sensitized by excessive inflammation

Obstruction of air flow

Inflamattion airway by cellular remodeling

Decrease in air flow

Increase in smooth muscle

Release of fibrogenic growth factors

There’s a deposit of collagen and elastolysis.

Bronchoconstriction: Abnormal smooth muscle contraction of the airways, intrinsic abnormality in the airway myocytes

Release of Acelticolin

Regulation of bronchial tone cells and proinflammatory cells

Airway Edema

Hypersecretion of mucus

Bronchial mucus plugging

Hypertrophy and cellular hyperplasia

ASTHMA

Types of Asthma

Mixed

Extrinsic Asthma

Intrinsic Asthma

Children with family history of major allergy triggers

Multifactorial Etiology

Autonomic Immune System and Nervous System

Increase in bronchial response

Wheezing, Shortness of breath, Intercostal Run,Tos and Chest tightness

Respiratory System

Chronic inflation of air routes

Allergies, Physical Exercise, Pharmacos, Environment and Emotions