Molecular Genetics

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Transcription factors bind

general factors

Molecular Genetics

Transcription

Regulation

post transcrip

Translastional

Rate of protein degradtion

chem modificationa

Inactive protein

rate of mRNA degradation: Poly a tail, proteins, hormones

masking proteins: inactivate

Alternate splicing

Methylation: Inhibits tanscrip

epigentics

chromatin accessability

Sepearting tighly wrapped histones

Intiation

RNA polymerase bind Promoter

open double helix

Builds 5' to 3', reads 3' to 5', template strand is bottom

elongation

termination

eukaryote

nuclear protein bind to termination site(string of adenines)

prokaryote

proteins bind to mRNA

binds to itself in hairpin loop

modifications: pre mRNA>mature mRNA

Translation

Ribosome

intiation

Termination

protein release factor binds

Elongation

Peptidly transferase

Ribsome shifts 1 codon, a >p, p>e

G cap bind to complex, scan for AUG, large subunit is added

tRna

Aminoacylation, by aminoacyl tRNA synthetase enzyme

Rna string, binds to itself forming clover shape

poly a tail, G cap

Rna splicing, group of ribonucleoproteins(snRPS) called splicesome bring exons close cleave out introns