Optic atrophy is a condition characterized by the degeneration of the optic nerve, leading to significant visual impairment. Symptoms often include blurred vision, abnormal color vision, and abnormal side vision.
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Lenaers et al.: Dominant optic atrophy. Orphanet Journal of Rare Diseases 2012 7:46.
Epidemiology
Age: Optic atrophy is seen in any age group.
Race:Optic atrophy is more prevalent in African Americans (0.3%) than in whites (0.05%).
-Prevalence of blindness attributable to optic atrophy was 0.8%.
MRN: 1000000002898
BCVA OU 20/200
Symptoms: Blurred vision, flashes of light, floaters
-38 Years old male African American
Histopathologic changes in optic atrophy
Widening of the subarachnoid space with redundant dura
Gliosis
Shrinkage or loss of both myelin and axis cylinders
Widening of the pial septa
Symptoms
Abnormal color vision
Abnormal side vision
Blurred vision
Causes
hereditary condition
Tumor
Stroke of the optic nerve
Glaucoma
Diagnosis
Molecular diagnosis by identification of a mutation in the OPA1 gene or in the OPA3 gene.
Thinning of retinal nerve fiber
Bilateral unexplained visual loss
Based on the findings of disc pallor associated changes in the integrity of the retinal nerve fiber layer and retinal vessels
visual dysfunction (vision and/or visual field loss)
