optic atrophy

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Reference:

Aijaz S, Erskine L, Jeffery G, Bhattacharya SS & Votruba M (2004): Developmental expression pro- file of the optic atrophy gene product: OPA1 is not localized exclusively in the mammalian retinal ganglion cell layer. Invest Ophthalmol Vis Sci 45: 1667–1673.

Osaguona VB, Okeigbemen VW. Nonglaucomatous optic atrophy in Benin City. Ann Afr Med 2015;14:109-13.

Lenaers et al.: Dominant optic atrophy. Orphanet Journal of Rare Diseases 2012 7:46.

Epidemiology

Age: Optic atrophy is seen in any age group.

Race:Optic atrophy is more prevalent in African Americans (0.3%) than in whites (0.05%).

-Prevalence of blindness attributable to optic atrophy was 0.8%.

MRN: 1000000002898

BCVA  OU 20/200

Symptoms: Blurred vision, flashes of light, floaters

-38 Years old male African American

Histopathologic changes in optic atrophy

Widening of the subarachnoid space with redundant dura

Gliosis

Shrinkage or loss of both myelin and axis cylinders

Widening of the pial septa

Symptoms

Abnormal color vision

Abnormal side vision

Blurred vision

Causes

hereditary condition

Tumor

Stroke of the optic nerve

Glaucoma

Diagnosis

Molecular diagnosis by identification of a mutation in the OPA1 gene or in the OPA3 gene.

Thinning of retinal nerve fiber

Bilateral unexplained visual loss

Based on the findings of disc pallor associated changes in the integrity of the retinal nerve fiber layer and retinal vessels

visual dysfunction (vision and/or visual field loss)