Kategoriak: All - synthesis - muscles - cytokines

arabera Tasnima Ahsan 5 years ago

297

Muscles

The text covers an array of topics related to muscle biology, emphasizing the mechanisms of muscle growth and atrophy. It delves into the structural components of muscles, such as the epimysium, perimysium, and endomysium, down to the cellular level including myofibrils and sarcomeres.

Muscles

via MRf(Myogenic regulotory factor

Embryonic Myogenesis

Gastrulation

mesodermal layer
lateral plate mesoderm
paraxial mesoderm

somites

Dermomyotome

Subtopic

myoblast

myocyte

multinucleated muscle fiber

myotome

Hypaxial

epaxial

muscle progenitor cells delamine from the edges of dermomyotome

sclerotomes

vertebrae and ribs

intermediate mesoderm
axial mesoderm

Muscles

Stem cells

Satellite cells
Myoblasts

Dormant stage

Other myoblasts

Myofibres

Muscle fiber

Sarcolemma and basal lamina
Myonuclei in postnatal skeletal muscle tissue

Structure

Epimysium
Perimysium

Endomysium

Single muscle fibers

Myofibril

Sarcomere

Actin fillament

Z disc

I band

H band

A band

Mysosin fillament

protein degradation

transcription factors
NF-kB

inflammatory cytokines

MuRF-1 activity

FOXO

mTOR

protein synthesis

Atrogin-1 activity

muscle atrophy

Protein synthesis

Myostatin-Smad3 pathway
mystatin actavin A

ACVR I/II

Smad 3 activity

negative regulator
Follistation
IGF1-Akt-mTor pathway
IGF-1

Pl3K

Akt

mTOR activity

muscle growth

muscle hypertrophy

positive regulator