The kidneys are critical organs responsible for filtering out waste products and environmental toxins from the blood, ensuring these substances are excreted in the urine. Failure in this filtration process leads to a dangerous accumulation of toxins, known as uremia, which can be fatal.
Through the Renin-angiotensin-aldosterone system(RAAS), kidneys co-ordinate with cardiovascular system and central nervous system, control blood pressure
Faillure of blood preesure control will to lead to an abnormal BP
abnormal BP will cause problem in Cardio-vascular system. Low BP will compromise hearth effectiveness. High BP can cause stroke
Filter out many waste product, environmental toxin into the urine for excretion.
failure to filter waste will increase unsafe level of waste and toxins in blood, uremia
Death
Convert Vitamin D, important for mineral metabolism and bone growth
failure of Vit D convection will lead to Vit D deficiency
Vit D deficiency will: decrease the immune system and make vulnerable to sickness. Fatigue
Renal tubule cells excrete hydrogen ions when the blood is to acidic and excrete bicarbonate ions when the blood is too alkaline. Maintain control over PH
in case of Failure of PH control, Blood will be too acidic or alkaline
Acidose has pro-inflammatery effect, exacerbate hyperkalemia while alkalosis potentiate detrimental effects of hypokalemia
Secrete erythropoietin when a low O2 level is detected to make red blood cells to increase O2 carrying capacity
Reduce of erythropoietin will lead to decrease of Red blood cells which will cause anemia
weakness, tiredness, SOB, fatigue
With Hormone control, nephrons excrete and reabsorb fluid and electrolyte in response to the needs of the body. Control fluid and electrolyte balance
Failure of fluid and electrolyte balance will lead to Hypovolemia, hypernatremia or hypervolemia, hyponatremia
Dehydration, weakness or swelling, edema, respiratory problems
