Kategóriák: Minden - inflammation

a cecle coulon 15 éve

245

vet clin path - coag

The text outlines various medical conditions and factors that influence blood coagulation and platelet disorders. It discusses conditions like thrombocytosis and thrombocytopenia, which involve abnormal platelet counts, and their causes ranging from genetic disorders to acquired conditions such as inflammation and autoimmune diseases.

vet clin path - coag

coag

thrombocytosis

splenectomy
myeloproliferation
excitement/EPI
inflammation
Fe deficiency anemia

hypercoagulability

nephritic syndrome

vascular abnormalities

Marfan

Ehlers Danlos

collagen disorders

Cushings

scurvy

endothelial injury

coagulopathy (hemorrhage)

factors
common (X, V, II, I)

ACT

PT

extrinsic (TF -> VII)

PT (-75%)

vit K antagonism

intrinsic (XII, XI, IX, VIII)

ACT (-95%)

PTT (-75%)

haemophiliacs

autoimmune dz
amyloidosis

- X lost to matrix

severe liver dz

+ FDP (not filtered out)

vit K antagonists
multifactorial
any other factor (sauf XII)
von Willebrand (vWF)
hemophilia A (VIII)

PTT

thrombopathy (petechiae)

thrombocytopathy
hereditary

thrombopathies

thrombasthenias

vWF

acquired

uremic plasma waste products

phenothiazine tranquilizers

autoimmune

FDPs

abnormal plasma proteins

NSAIDs

thrombocytes > 10-50k
BMBT
thrombocytopenia
sepsis (LA)
+ sequestration

splenomegaly

+ destruction

ehrlichiosis

iatrogenic heparin

ITP (ca)

+ consumption

vasculitis

hemangiosarcoma

DIC

- ATIII

schistocytes

+ D dimers

+ FDP

- fibrinogen

- then + PTT, PT

- production
macroplatelets

regenerative

± BMBT
thrombocytes < 10-50k