RED BLOOD CELL LIFE CYCLE

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Concepts

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De-oxygenated RBCs

Dietary Vitamin B12

Co-enzyme in DNA production

Dietary Folic Acid

Nucleic Acid synthesis for DNA

Small Intestine

iron + Apotransferrin

=Transferrin

Stomach

Intrinsic factor

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Heart

Lungs

Oxygenated RBCs

Arterial System

Body Cells

heme converted to bilirubin

Liver

Iron stored as Ferritin

Bone Marrow

Pluripoint stem cells

Proerythroblasts

Multiple divisions

accumulates Hemoglobin

Nucleus lost

Loses mitochondria and ribosomes

Reticulocytes released into circulatory system

Mature Red Blood Cells

Sternum, Pelvis, Vertebrae

Spleen

Recylced Heme from destroyed RBCs

IRON

Old RBCs

Kidney

Erythropoietin

LOW OXYGEN

DIETARY IRON

RED BLOOD CELL LIFE CYCLE