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Intrinsic
Enzyme Deficiency
Pyruvate kinase
G6PD
HgB abnormal
Sickle cell Disease
Membrane defect
Paroxysmal nocturnal hemoglobinuria
Hereditary elliptocytosis
Hereditary spherocytosis
Extrinsic
Malaria
Micro/macroangiopathic hemolytic anemia
Immune hemolytic anemia
Blood loss > 1 week
Common cause: Chronic inflamm. (e.g. RA)
↑ferritin (> 100 ng/mL)