Hypothalamus

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Hypothalamus

Lateral Hypothalamic Region

Appetite and Thirst regulation Lesion of the lateral hypothalamus leads to loss of appetite (aphagia), starvation, and death

Medial Region

mammillary

Posterior

When stimulated increased shivering Sympathetic Nervous System Lesion (Horners) will increased BP and decrease Body Temp which may result in shivering

Suckling Reflex

Tuberal

Periventricular

Dopamine or PIF release

GIH or somatostatin release

Dorsomedial

GI Tract

Under tonic inhibition

Arcuate

Under dual antagonistic control of Leptin

It decreases the production of agouti-related protein (AgRP ), which acts on the paraventricular nucleus to decrease TRH

Leptin will increases production of proopiomelanocortin (POMC) which is converted into α-MSH and that acts on the paraventricular nucleus to increase TRH.

Release of GHRH

Anterior

Stimulation will decrease Body Temperature/ Parasympathetic Lesion will result in hyperthermia

Ventromedial

Satiety

Lesion will cause result in hyperphagia Stimulation will cause cessation fo feeding

Supraoptic

suprachiasmatic

Circadian Clock

Medial Preoptic

GnRH

Supraoptic

ADH/Oxytocin/CRH

Paraventricular

Corticotropin Release Hormone

Production center for TRH

Under control of Leptin which Increases TRH production

ADH/Oxytocin Osmoreceptors are located in Anterior hypothalamus