Kategorien: Alle - synthesis - purification - reduction

von Tony Zoltika Vor 17 Jahren

225

Rearrangements

The text covers various chemical processes and methodologies focusing on the transformation and purification of organic compounds. It details the reduction of ketones and the use of LDA in synthesis and rearrangement processes.

Rearrangements

Reduction of ketone

Johnson

- cyclization of carboxylic acid to cyclic ketone

Saucy-Marbet

- rearrangement

- synthesis of Grignard-reagent

- treatment with Grignard-reagent of aldehyde

- cyclization of product to alkyl-laktone

- reduction of aldehyde with NaBH4

- cyclization of second OH to lactone

Ireland

- acylation and purification
- LDA synthesis and actual rearrangement

- purification

- cyclization of (alkyl) carboxylic acid to alkylated cyclic ketone

ester hydrolysis