EFFECT OF FREE RADICALS

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EFFECT OF FREE RADICALS

PTN cross linking

cystine - lysine - methionine - histidine

enzyme inactivation :Sulfa-hydral enzyme

DNA damage

3- Mutations or cell Killing

2- single strand DNA

1- free radical with thymine =Oxidation

Non-peroxidative mito mem damage

Fenton reaction

Xanthene oxidase

lipid peroxidation of Membranes

free radical attach to double bond of mem form : Lipid peroxide

this LIPID peroxide: unstable & Reactive= extensive damage to All membranes