Kategoriak: All - enzyme - damage - mutations - dna

arabera Retaj mohammed 2 years ago

226

EFFECT OF FREE RADICALS

Free radicals can cause significant damage to biological membranes and DNA through various mechanisms. One major consequence is the lipid peroxidation of membranes, where free radicals attach to double bonds in lipids, forming lipid peroxides.

EFFECT OF FREE RADICALS

EFFECT OF FREE RADICALS

PTN cross linking

cystine - lysine - methionine - histidine
enzyme inactivation :Sulfa-hydral enzyme

DNA damage

3- Mutations or cell Killing
2- single strand DNA
1- free radical with thymine =Oxidation

Non-peroxidative mito mem damage

Fenton reaction
Xanthene oxidase

lipid peroxidation of Membranes

free radical attach to double bond of mem form : Lipid peroxide
this LIPID peroxide: unstable & Reactive= extensive damage to All membranes

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