Luokat: Kaikki - treatment - clinical - enzymes - resistance

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815

Gram (+) Flow Chart

Staphylococcus aureus, a Gram-positive microbe, can cause various infections ranging from minor skin conditions to severe systemic diseases. Its pathogenicity is driven by several factors, including enzymes like coagulase and penicillinase, which help in evading the host immune response, and tissue-destroying enzymes such as hyaluronidase.

Gram (+) Flow Chart

Pathogenic Gram(+) Microbes

Cocci

Hemolysis

None (γ)

Bile Esculin

Partial (α)

Optochin "P"

S. Viridans

Dental Carries

S. Pneumoniae

Quellung

Vaccine

w/ Lung disease

w/ Heart disease

Vanco

Cefotaxime

Lancet-shaped

Asplenic

Complete (β)

Bacitracin "A"

CAMP

S. agalactiae (GBS)

Neonatal meningitis

S. Pyogenes (GAS)

Cephalosporin

Post-Strep

Glomerulonephritis

Acute Rheumatic fever

Necrotizing Fasciitis

Scarlet Fever

Skin

Puerperal sepsis

Erysipelas

Cellulitis

Pharyngitis "Strep Throat"

Staph/Micro

Coagulase

Modified Oxidase

Novobiocin

S. saprophyticus

Penicillin

UTI

Sexually-active women

Micrococcus

Opportunistic

Packets of 8!

Immunocompromised

No Treatment required

S.Aureus

Clinical

Food Poisoning

Systemic

Inflammation

Endocarditis

Arthritis

Osteomyelitis

Purpura fulminans

SSS

TSS

Cutaneous

Folliculitis

Furuncles

Impetigo

Boils

MRSA

I.V. Vanco

First Gen. Cephalosporin

Cephalothin

Anti-staph penicillins

Methicillin

Nafcillin

Resist Beta-lactamase

TSST-1

Toxic Shock Syndrome

Gastroenteritis (Food Poisoning)

Exfoliatin

Scalded Skin Syndrome

Enzymes

Tissue-Destroying

Lipase

Staphylokinase

Hyaluonidase

Protective

Penicillinase

Leukocidins

Hemolysins

Protein A

Rods

Form Endospores
Corynebacterium / Listeria

Facultative anaerobes

Aerobic preferred

Catalase

Motile / Cold enrichment

Corynebacterium

C. diptheriae

Diagnosis

Elek Immunodiffusion

Tellurite medium

DPT Vaccine

Tetanus

Pertussis

Diptheria

Reimmu. every 10 yrs.

Toxoid (B)

Penicillin / Erythromycin

Antitoxin

Toxin

Exotoxin (Coded by phage)

Lethal @ 0.1 ug/kg

Cardiac/Neural Tissue (B)

Blocks protein synthesis (A)

Tetracycline Analog

ADP-ribosylates EF-2

Reservoir

Human ONLY

Rare in U.S.

Direct Contact

Respiratory Droplets

Carriers

Immune (Skin)

Asymptomatic (Oral)

Club-shaped

Nasopharynx

C. jeikeium

I-suppressed

Nosocomial

Catheters / Heart Valves

Bacteremia

C. ulcerans

Can cause mild disease

L. monocytogenes

No vaccine

Penicillin / Ampicillin

Toxins

Phospholipases

Listeriolysin O

Epi

Those @ Risk

Meningitis

HIV

Elderly

Neonates

Pregnant & septic

Transmission

Intrauterine

Foodborne

Unpasteurized Dairy

Tumbling @ Room Temp.

Intracellular Spread

Colonization

Intestinal

Bacillus

Aerobes

Penicillin resistant?

B. Anthracis

Treatment

Doxycycline

Ciprofloxacin

PA Vaccine

Exotoxin

Lethal Factor (A)

Protective Antigen (B)

Edema Factor (A)

Herbivores

Cattle

Goats

Sheep

Bamboo-like chains

Facultative Anaerobe

B. Cereus

Characteristics

NO protein capsule

Motile

Enterotoxins

Heat labile/stable

Food poisoning (Rice)

Vomiting/Diarrhea

Vancomycin