Certain medications target specific 5-HT (serotonin) receptors to treat various conditions. For instance, Olanzapine acts as a 5-HT 2a antagonist and is used as an antipsychotic. Cyproheptadine, which blocks HT2 receptors, is used for treating carcinoid and gastrointestinal tumors and also works for seasonal allergies due to its H1 blocking effects.
Antiemetic in chemotherapy, radiation and postoperatively
An ion channel (no 2nd messengers)
Found in area of posterma, peripheral sensory and enteric nerves
5HT 2(a-c)
Cyproheptadine
Has H1 blocking effects, so it's used for seasonal allergy
Octreotide is a better drug however
Antagonist for HT2 in carcinoid and G.I tumors
Olanzapine
Antipsychotic
5HT 2a antagonist
In periphery: Vasodilation (flushing), contraction of G.I muscles (diarrhea), contraction of bronchioles, uterine smooth muscles and platelet aggregation
Found in CNS (excitatory)
5HT 1(a-h)
Sumatriptan
Side effects: possible asthenia, throat or chest pain
Lowers migrain pain by causing vasoconstriction
Agonist at 5HT 1d in cerebral vessels
buspirone
Anxiolytic (Generalised anxiety disorder, GAD)
Remember "a for anxiety"
