da Felicia MedStudent mancano 16 anni
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Valsartan
MOA: blocks binding of AT II to AT-1 receptors (same as losartan K)
food markedly decreases absorbtion
Diovan HCT
Losartan Potassium
MOA: blocks binding of AT II to AT-1 receptors
*more efficacious in reducing the action of AT II
actions:
available in combo with HCTZ
Hyzaar
NO COUGH!
dizziness
Use for:
- esp diabetic nephropathy <--ACE or ARB
all are renal sparing, so they do not increase transglomerular pressure
Lisinopril
advantages
Enalapril
MOA: same as captopril
advantages:
bioavailability not affected by food
qd dosing
IV admin
No sulfhydryl group so fewer AEs
has carboxyl group instead
AE
no hypogustia
Captopril
MOA: blocks conversion of AT I -> AT II and increases activity of bradykinin (which breaks down vasodilators to inactive peptides)
(1) decreases production of vasoconstrictors (AT II)
(2) decreases destruction of vasodilators (bradykinin)
renal sparing
does not increase transglomerular pressure
which would lead to glomerular damage
drug interactions
w/ triamterene or amiloride
AE:
increased renin and AT I production
hypoglycemia
rash (hypersensitivity)
neutropenia
proteinuria
non-productive cough
b/c increased bradykinin stimulates the cough reflex
hypogustia (loss of taste)
hyperkalemia
Amiloride
Triamterene
Eplerenone
much more specific mineralocorticoid antag
Spironolactone
binds to mineralocorticoids, androgen, AND progestin receptors
in combo with glucocorticoids, are used as replacement in adrenal insufficiency
IV or IM in oil
DoC, oral
eg. Clonidine, Methyldopa
eg, Propranolol
renin inhibitor
