によって James Sommer 7か月前.
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G q
Upon ligand binding, 'G alpha Q' dissociates and GDP-> GTP. Activates Phospholipase which then converts PIP3 (in membrane) to IP3 and DAG. DAG activates PKC which goes on to phosphorylate substrates. IP3 travels across the cytosol to the ER where it binds to Ca2+ channels to allow for the outpour of Ca2+ into the cytosol.
G alpha i
Upon ligand binding, 'G alpha I' protein dissociates from complex and GDP -> GTP. The protein then inhibits AC so that no cAMP is produced, and thus PKA remains inactive.
G alpha s
Upon ligand binding, 'G alpha s' protein dissociates from complex and GDP-> GTP. Activates AC. AC converts ATP to cAMP which goes on to activate PKA.