Viruses and Cancer

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Viruses and Cancer

RNA Oncogenic Viruses

Subtopic

human T-cell leukemia

only from family Retroviridae

DNA Oncogenic Viruses

hepatitis B

Epstein-Barr virus

human papillomavirus

Transformation of Normal Cells into Tumor Cells

less round than normal cells and show abnormalities

T antigen...antigen in nucleus of tumor cell

tumor specific transplantation antigen...antigen on cell surface

tumor cells undergo transformation

oncogenic viruses: 10% of cancers

Bishop and Varmus: Nobel 1989..cancer-inducing genes carried by viruses are actually derived from animal cells

affect parts of the genome called oncogenes

Unrecognized because:

cancers are not contagious like viral diseases usually are

cancer may not develop until long after infection

most of the particles infect cells but do not induce cancer

adenocarcinomas in mice were discovered in 1936...virus-induced

Sarah Stewart..discovered and isolated human cancer-causing virus

first demonstrated in 1908 by Wilhelm Ellermand and Olaf Bang...causative agent of chicken leukemia

F Peyton Rous...chicken sarcoma