Категории: Все - heart

по sayma abdulrasool 3 лет назад

438

Organigram

The discussed topic revolves around the treatment and mechanisms associated with heart failure, particularly focusing on reduced ejection fraction. Two principal systems are highlighted:

Organigram

Heart failure with reduced ejection fraction

Renin angiotensin aldosterone system

angiotensin ll
Valsartan( inhibit angiotensin ll)
AT2 receptor

increase vasoconstriction

increase heart hypertrophy

increase aldosterone

increase blood pressure

Natriuretic peptide system

natriuretic peptides
Sacubitril( inhibit enzyme neprilysin) produce inactive fragment

increase bradykinin and angiotensin ll

increase vasodilation

decrease heart hypertrophy

decrease aldosterone

decrease blood pressure