Hyperlipidemia

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Hyperlipidemia

↓intracell cholesterol = ↑LDL receptor = ↓plasma [LDL]

Both

Niacin

Cutaneous flush, pruritis

Aspirin 30 min. prior

Triglycerides

N3FAs

Marine Oils

Gemfibrozil

↑LDL receptors on membrane

Rash

Fibrates

Interactions

Inhibits platelet aggregation

Displaces warfarin

Arrhythmia in CAD

Flu-like syndrome

Clofibrate

Fenofibrate

NOT available in the U.S. but sold in Canada

↑HDL

PPAR-alpha

↑LPL expression

Cholesterol

Ezetimibe

Blocks cholesterol absorption @ enterocyte

Niemann-Pick C1-like protein

Bile-acid exchanger

Acidic Drugs

Thyroxine

Thiazides

Tetracycline

Iron

Hydrocortisone

Vit. A,D,E,K

Phenobarbital

Warfarin

Digoxin

Side Fx

↑VLDL

GI

Tastes like sand

Pruritis a/w biliary obstruction

Drugs

Colesevelam

Colestipol

Cholestyramine

Statin

Those with CVD should be on a statin.

Pregnancy

Others

Inhibits VLDL synth.

Prava

Single day dosing

Atorva

Simva

Super-

Pitava

Rosuva

Lovastatin