Kategorier: Alle - pregnancy

af R G 15 år siden

1089

Hyperlipidemia

Statins are commonly prescribed for individuals with cardiovascular disease to manage cholesterol levels. By reducing intracellular cholesterol, statins increase LDL receptors, thereby decreasing plasma LDL concentrations.

Hyperlipidemia

Hyperlipidemia

↓intracell cholesterol = ↑LDL receptor = ↓plasma [LDL]

Both

Niacin
Cutaneous flush, pruritis

Aspirin 30 min. prior

Triglycerides

N3FAs

Marine Oils

Gemfibrozil
↑LDL receptors on membrane
Rash
Fibrates
Interactions

Inhibits platelet aggregation

Displaces warfarin

Arrhythmia in CAD
Flu-like syndrome
Clofibrate
Fenofibrate

NOT available in the U.S. but sold in Canada

↑HDL
PPAR-alpha
↑LPL expression

Cholesterol

Ezetimibe
Blocks cholesterol absorption @ enterocyte
Niemann-Pick C1-like protein
Bile-acid exchanger
Acidic Drugs

Thyroxine

Thiazides

Tetracycline

Iron

Hydrocortisone

Vit. A,D,E,K

Phenobarbital

Warfarin

Digoxin

Side Fx

↑VLDL

GI

Tastes like sand

Pruritis a/w biliary obstruction
Drugs

Colesevelam

Colestipol

Cholestyramine

Statin

Those with CVD should be on a statin.

Pregnancy
Others

Inhibits VLDL synth.

Prava

Single day dosing

Atorva

Simva

Super-

Pitava

Rosuva

Lovastatin