Kategóriák: Minden - inflammation - iron - cytokines - anemia

a Brenda Mitchell 4 éve

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ANEMIA of CHRONIC INFLAMMATION

Anemia of chronic inflammation is a condition where the body's response to prolonged inflammation leads to disturbances in red blood cell (RBC) production and iron metabolism. This type of anemia is frequently associated with autoimmune diseases, infections, malignancies, burns, and trauma.

ANEMIA of CHRONIC INFLAMMATION

Treatments

Erythropoisis stimulating agents

Treat inflammation

Treat underlying cause of inflammation

Blood transfusions

DIAGNOSTIC LABS

Increased Ferritin levels

Low serum iron

Decreased Transferrin saturation

CBC - low RBCs

Brenda Mitchell

Liver

Bone Marrow

Pluripoint stem cells

Proerythroblasts
Multiple divisions

accumulates Hemoglobin

Nucleus lost

Loses mitochondria and ribosomes

Reticulocytes released into circulatory system

Mature Red Blood Cells

Spleen

Iron stored as Ferritin

ANEMIA of CHRONIC INFLAMMATION

Systemic Inflammation

Auto Immune diseases, Infections, Malignancies, Burns, Trauma
Increased Cytokine production

Decrease Iron availability

Increased RBC Destrucion

Decrease RBC productio