Clinical Use of Psychedelics
Neural plasticity
wikipedia
Mc Clure 2022
Induction of spine formation.
cortical neurons in vitro and in vivo by activating 5- HT2A receptors. Furthermore, we have found that many of the biochemical and behaviorl actions of psychdlcis are dependenct on the 5 ht 2a receptor interactioons with synapetic scaffolding protiens that are enriched in dendritic spine. Anti-depressansts can also induce spine formation and synarpic plasticity . This supposrts a mode;l for tx actions of delciss that point to a process that could enhncce synatoic plasticity.
Recently, we discovered and others99,100 confirmed that psychedelics can alter synaptic plasticity by enhancing dendritic spine formation on
An apical dendrite is a dendrite that emerges from the apex of a pyramidal cell.[1] Apical dendrites are one of two primary categories of dendrites, and they distinguish the pyramidal cells from spiny stellate cells in the cortices. Pyramidal cells are found in the prefrontal cortex, the hippocampus, the entorhinal cortex, the olfactory cortex, and other areas.[2] Dendrite arbors formed by apical dendrites are the means by which synaptic inputs into a cell are integrated.[3] The apical dendrites in these regions contribute significantly to memory, learning, and sensory associations by modulating the excitatory and inhibitory signals received by the pyramidal cells.
Actual Research
Analysis of live 5Meo expeprience
Pre Post MD LSD
Pre post EEG 5 Meo
Results
Right Angular Gyrus
Choices Analytical
How it was done
Social
Cognition
There is simply too much interveaved cortical functionality
Feel this is a red herring
What is the primary purpose of the brain
Delics and empathy
Delics lead to a pre-empthay state
Overall, clinical and social neuroscience research lends strong support to the notion that emotion reactivity in general, particularly the sharing of another’s distress, plays a pivotal role in facilitating prosocial behaviour.
the recognion, acceptance and non threatening awareness of more than me?
not so sure delics do that
leads to emotional contagion
feeling for what others feel?
Human Intelligence is Social Intelligence
Behaviors that can be described as prosocial include feeling empathy and concern for others.
we
us
Me
Therefore, makes sense to examine the effects of psychedelics on social intelligence rather than focusing on the effects psychedelic's on cognition.
Where to integrate Hoffmans work on evolution of the fit
Brain can navigate multiple disparate problems -- but the heart of all problems it navigates is social relations (Robin Dunbar Evolutionary psychologist at University of Oxford)
Navigate social relationships
Navigate current environment?
Balance the three F's
