Categorias: Todos - side-effects - contraindications - pharmacokinetics - cardiovascular

por Michelle Hahn 4 anos atrás

636

Propanolol concept map

Propanolol, a nonselective beta blocker, is extensively used to treat various cardiovascular conditions such as hypertension, angina, coronary heart disease, and arrhythmias. It is completely absorbed in the body, with maximum plasma concentrations occurring within 1 to 3 hours post-ingestion.

Propanolol concept map

Propanolol

side effects

overdose side effect: slow heartbeat
rash/swelling/hives/itching
difficulty breathing
constipation
diarrhea
tiredness
dizziness
abrupt withdrawal is associated with tachycardia, angina pectoris, and rarely myocardial infarction

drug interactions

anesthesia with epinephrine
blood pressure drugs: ACE inhibitors, other beta blockers, or alpha blockers
Blood thinning drugs
NSAIDS may reduce effectivness of drug

contraindications

severe low blood pressure
shock syndrome
Atrioventricular Valve block
bradycardia
COPD
smoking

indications

angina pectoris
arrythmia
coronary heart disease
hypertension

general dosages

80mg orally 1x/day

dental applications/considerations

oral lichenoid reaction
altered/loss sense of taste
xerostomia --> increased caries risk
used to reduce patient anxiety before extractions or post extractions to minimize dental-related apprehension. This practice has not been studied
Subtopic
monitor patient's vital signs throughout appointment and minimize any stressful activities that could elevate hypertensive patient's vitals
chronic propanolol therapy and lidocaine with epinephrine administration is associated with hypertensive blood pressure

function

reduce release of renin from juxtaglomerular apparatus
reduced sympathetic activity
reduce cardiac stroke volume
reduce heart rate

purpose

prevent strokes/myocardial infarction/cardiac arrythmias
nonselective Beta blocker
anti-hypertensive drug

pharmacodynamics

influence antisympathetic activity in CNS
is lipid soluble and crosses blood-brain barrier
sodium-channel blocking and prevents action potential propagation down an axon
blocks action of epinephrine and norepinephrine at Beta 1 and 2 adrenergic receptors

pharmokinetics

metabolites are excreted in urine
main metaoblite hydroxypropanolol is 5.2 to 7.5 hours
first pass metabolism: drug is metabolized at liver resulting in reduced systemic concentrations
>90% of drug is bound to plasma proteins in the blood
maximum plasma levels occurs 1-3 hours after ingestion
completely absorbed